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The Dangers of Vaping CBD Oil (Potential Risks of PEG, PG, and Winterization of CBD oil is a technique that involves removing all (or at least a portion of) the waxes, fatty acids, and lipids, which have higher melting points than other parts of the plant. If you’re unsure whether or not a specific CBD vape juice has undergone winterization, call the company and ask them. If they can’t tell you, then Cannabidiol - Wikipedia Cannabidiol may be an antagonist of GPR55, a G protein-coupled receptor and putative cannabinoid receptor that is expressed in the caudate nucleus and putamen in the brain. It also may act as an inverse agonist of GPR3, GPR6, and GPR12. CBD has been shown to act as a serotonin 5-HT 1A receptor partial agonist.